Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival
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چکیده
منابع مشابه
Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival
Nuclear factor, erythroid 2-like 2 (NFE2L2), a transcription factor also known as NF-E2-related factor 2 (Nrf2), is a key cytoprotective gene that regulates critical antioxidant and stress-responsive genes. Nrf2 has been demonstrated to be a promising therapeutic target and useful biomarker in malignant disease. We hypothesized that NFE2L2-mediated gene expression would reflect cancer severity ...
متن کاملErratum: Antioxidant mechanism of black garlic extract involving nuclear factor erythroid 2-like factor 2 pathway
[This corrects the article on p. 206 in vol. 11, PMID: 28584577.].
متن کاملRegulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.
We have previously shown that cadmium, a metal that alters cellular redox status, induces CYP2A5 expression in nuclear factor (erythroid-derived 2)-like 2 wild-type (Nrf2+/+) mice but not in the knockout (Nrf2-/-) mice. In the present studies, the potential role of Nrf2 in cadmium-mediated regulation of Cyp2a5 gene was investigated in mouse primary hepatocytes. Cadmium chloride (CdCl2) caused a...
متن کاملAntioxidant mechanism of black garlic extract involving nuclear factor erythroid 2-like factor 2 pathway
BACKGROUN/OBJECTIVES Although studies have revealed that black garlic is a potent antioxidant, its antioxidant mechanism remains unclear. The objective of this study was to determine black garlic's antioxidant activities and possible antioxidant mechanisms related to nuclear factor erythroid 2-like factor 2 (Nrf2)-Keap1 complex. METHODS/MATERIALS After four weeks of feeding rats with a normal...
متن کاملGenomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2
High-density mapping of mammalian genomes has enabled a wide range of genetic investigations including the mapping of polygenic traits, determination of quantitative trait loci, and phylogenetic comparison. Genome sequencing analysis of inbred mouse strains has identified high-density single nucleotide polymorphisms (SNPs) for investigation of complex traits, which has become a useful tool for ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep16889